- Title
- Anxiety, depression and fatigue at 5-year review following CNS demyelination
- Creator
- Simpson, S.; Tan, H.; Williams, D.; van der Mei, I.; Ausimmune/AusLong Investigators Group,; Otahal, P.; Taylor, B.; Ponsonby, A.-L.; Lucas, R. M.; Blizzard, L.; Valery, P. C.; Lechner-Scott, J.; Shaw, C.
- Relation
- NHMRC.1083090, NHMRC.316901, NHMRC.224215 http://purl.org/au-research/grants/nhmrc/1083090
- Relation
- Acta Neurologica Scandinavica Vol. 134, Issue 6, p. 403-413
- Publisher Link
- http://dx.doi.org/10.1111/ane.12554
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2016
- Description
- Background: Anxiety and depression are common in multiple sclerosis (MS). We evaluated the prevalence and factors associated with anxiety, depression and fatigue at the 5-year review of a longitudinal cohort study following a first clinical diagnosis of CNS demyelination (FCD). Methods: Cases with a FCD were recruited soon after diagnosis and followed annually thereafter. A variety of environmental, behavioural and clinical covariates were measured at five-year review. Anxiety and depression were measured using the Hospital Anxiety & Depression Scale (HADS), and fatigue by the Fatigue Severity Scale (FSS). Results: Of the 236 cases, 40.2% had clinical anxiety (median HADS-A: 6.0), 16.0% had clinical depression (median HADS-D: 3.0), and 41.3% had clinical fatigue (median FSS: 4.56). The co-occurrence of all three symptoms was 3.76 times greater than expectation. Younger age, higher disability, concussion or other disease diagnosis were independently associated with a higher anxiety score; male sex, higher disability, being unemployed, less physical activity, and antidepressant and/or anxiolytic-sedative medication use were independently associated with a higher depression score. Higher disability, immunomodulatory medication use, other disease diagnosis and anxiolytic-sedative medication use were independently associated with having fatigue, while female sex, higher BMI, having had a concussion, being unemployed and higher disability were associated with a higher fatigue score. Conclusion: These results support previous findings of the commonality of anxiety, depression and fatigue in established MS and extend this to post-FCD and early MS cases. The clustering of the three symptoms indicates that they may share common antecedents.
- Subject
- multiple sclerosis; prevalence; anxiety; depression; fatigue; first demyelinating event
- Identifier
- http://hdl.handle.net/1959.13/1347159
- Identifier
- uon:29982
- Identifier
- ISSN:0001-6314
- Language
- eng
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